Anti-Inflammatory Effect of Local Anaesthetic Ropivacaine in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

Li Wu; Lu Li; Fang Wang; Xianwei Wu; Xin Zhao; Na Xue

doi:10.1159/000496425

Anti-Inflammatory Effect of Local Anaesthetic Ropivacaine in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

Li Wu
, Lu Li
, Fang Wang
, Xianwei Wu
, Xin Zhao
, Na Xue

School of Materials Science and Engineering

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The present manuscript intended to investigate the anti-inflammatory effect of ropivacaine on lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. Results suggested that ropivacaine causes significant inhibition of generation of nitric oxide (NO), prostaglandin E2, tumor necrosis factor (TNF)-a, interleukin (IL)-6, and IL-1B, as well as expression of their synthesizing enzymes, inducible NO synthase, and cyclooxygenase-2. Moreover, ropivacaine causes inhibition of mitogen-activated protein kinases as well as nuclear factor-kappa B signaling pathway and apoptosis in RAW 264.7 cells. Based on the results, it has been suggested that ropivacaine showed beneficial effect against inflammation. 2019 S.

Original language	English
Pages (from-to)	228-235
Number of pages	8
Journal	Pharmacology
Volume	103
Issue number	5-6
DOIs	https://doi.org/10.1159/000496425
State	Published - 1 Apr 2019

Keywords

Apoptosis
Cytokine
Inflammation
Mitogen-activated protein kinases
Nuclear factor-kappa B

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10.1159/000496425

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title = "Anti-Inflammatory Effect of Local Anaesthetic Ropivacaine in Lipopolysaccharide-Stimulated RAW264.7 Macrophages",

abstract = "The present manuscript intended to investigate the anti-inflammatory effect of ropivacaine on lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. Results suggested that ropivacaine causes significant inhibition of generation of nitric oxide (NO), prostaglandin E2, tumor necrosis factor (TNF)-a, interleukin (IL)-6, and IL-1B, as well as expression of their synthesizing enzymes, inducible NO synthase, and cyclooxygenase-2. Moreover, ropivacaine causes inhibition of mitogen-activated protein kinases as well as nuclear factor-kappa B signaling pathway and apoptosis in RAW 264.7 cells. Based on the results, it has been suggested that ropivacaine showed beneficial effect against inflammation. 2019 S.",

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author = "Li Wu and Lu Li and Fang Wang and Xianwei Wu and Xin Zhao and Na Xue",

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AU - Wu, Li

AU - Li, Lu

AU - Wang, Fang

AU - Wu, Xianwei

AU - Zhao, Xin

AU - Xue, Na

N1 - Publisher Copyright: © Karger AG, Basel.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - The present manuscript intended to investigate the anti-inflammatory effect of ropivacaine on lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. Results suggested that ropivacaine causes significant inhibition of generation of nitric oxide (NO), prostaglandin E2, tumor necrosis factor (TNF)-a, interleukin (IL)-6, and IL-1B, as well as expression of their synthesizing enzymes, inducible NO synthase, and cyclooxygenase-2. Moreover, ropivacaine causes inhibition of mitogen-activated protein kinases as well as nuclear factor-kappa B signaling pathway and apoptosis in RAW 264.7 cells. Based on the results, it has been suggested that ropivacaine showed beneficial effect against inflammation. 2019 S.

AB - The present manuscript intended to investigate the anti-inflammatory effect of ropivacaine on lipopolysaccharide-induced inflammation in RAW 264.7 macrophages. Results suggested that ropivacaine causes significant inhibition of generation of nitric oxide (NO), prostaglandin E2, tumor necrosis factor (TNF)-a, interleukin (IL)-6, and IL-1B, as well as expression of their synthesizing enzymes, inducible NO synthase, and cyclooxygenase-2. Moreover, ropivacaine causes inhibition of mitogen-activated protein kinases as well as nuclear factor-kappa B signaling pathway and apoptosis in RAW 264.7 cells. Based on the results, it has been suggested that ropivacaine showed beneficial effect against inflammation. 2019 S.

KW - Apoptosis

KW - Cytokine

KW - Inflammation

KW - Mitogen-activated protein kinases

KW - Nuclear factor-kappa B

UR - https://www.scopus.com/pages/publications/85061011918

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DO - 10.1159/000496425

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JO - Pharmacology

JF - Pharmacology

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ER -

Anti-Inflammatory Effect of Local Anaesthetic Ropivacaine in Lipopolysaccharide-Stimulated RAW264.7 Macrophages

Abstract

Keywords

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