Anti-inflammatory components isolated from Atractylodes macrocephala Koidz

Haiyan Dong; Langchong He; Meng Huang; Yalin Dong

doi:10.1080/14786410801931629

Anti-inflammatory components isolated from Atractylodes macrocephala Koidz

Haiyan Dong
, Langchong He
, Meng Huang
, Yalin Dong

Health Science Center

Research output: Contribution to journal › Article › peer-review

111 Scopus citations

Abstract

The petroleum ether-ether (1:1) extract of Atractylodis macrocephalae was screened by cell membrane chromatography (CMC) and subsequently separated by column chromatography (CC) and high performance liquid chromatography (HPLC). Five components were isolated and identified as atractylenolide III 1, atractylenolide I 2, 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol 3, 14-acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 4 and 14-acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 5 by routine spectrometric methods. The data of 5 and ¹³C-NMR data of 3 and 4 were reported for the first time. Further in vivo experiments showed that the five components exhibited significant inhibiting effects both on the ear edema induced by xylene and on the peritoneal capillary permeability induced by acetic acid in mice.

Original language	English
Pages (from-to)	1418-1427
Number of pages	10
Journal	Natural Product Research
Volume	22
Issue number	16
DOIs	https://doi.org/10.1080/14786410801931629
State	Published - 10 Nov 2008

Keywords

14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol
14-acetoxy-12-α-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol
Anti-inflammatory effects
Atractylenolide I
Atractylenolide III
Atractylodis macrocephalae

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title = "Anti-inflammatory components isolated from Atractylodes macrocephala Koidz",

abstract = "The petroleum ether-ether (1:1) extract of Atractylodis macrocephalae was screened by cell membrane chromatography (CMC) and subsequently separated by column chromatography (CC) and high performance liquid chromatography (HPLC). Five components were isolated and identified as atractylenolide III 1, atractylenolide I 2, 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol 3, 14-acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 4 and 14-acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 5 by routine spectrometric methods. The data of 5 and 13C-NMR data of 3 and 4 were reported for the first time. Further in vivo experiments showed that the five components exhibited significant inhibiting effects both on the ear edema induced by xylene and on the peritoneal capillary permeability induced by acetic acid in mice.",

keywords = "14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol, 14-acetoxy-12-α-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol, Anti-inflammatory effects, Atractylenolide I, Atractylenolide III, Atractylodis macrocephalae",

author = "Haiyan Dong and Langchong He and Meng Huang and Yalin Dong",

year = "2008",

month = nov,

day = "10",

doi = "10.1080/14786410801931629",

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T1 - Anti-inflammatory components isolated from Atractylodes macrocephala Koidz

AU - Dong, Haiyan

AU - He, Langchong

AU - Huang, Meng

AU - Dong, Yalin

PY - 2008/11/10

Y1 - 2008/11/10

N2 - The petroleum ether-ether (1:1) extract of Atractylodis macrocephalae was screened by cell membrane chromatography (CMC) and subsequently separated by column chromatography (CC) and high performance liquid chromatography (HPLC). Five components were isolated and identified as atractylenolide III 1, atractylenolide I 2, 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol 3, 14-acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 4 and 14-acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 5 by routine spectrometric methods. The data of 5 and 13C-NMR data of 3 and 4 were reported for the first time. Further in vivo experiments showed that the five components exhibited significant inhibiting effects both on the ear edema induced by xylene and on the peritoneal capillary permeability induced by acetic acid in mice.

AB - The petroleum ether-ether (1:1) extract of Atractylodis macrocephalae was screened by cell membrane chromatography (CMC) and subsequently separated by column chromatography (CC) and high performance liquid chromatography (HPLC). Five components were isolated and identified as atractylenolide III 1, atractylenolide I 2, 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol 3, 14-acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 4 and 14-acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 5 by routine spectrometric methods. The data of 5 and 13C-NMR data of 3 and 4 were reported for the first time. Further in vivo experiments showed that the five components exhibited significant inhibiting effects both on the ear edema induced by xylene and on the peritoneal capillary permeability induced by acetic acid in mice.

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KW - 14-acetoxy-12-α-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol

KW - Anti-inflammatory effects

KW - Atractylenolide I

KW - Atractylenolide III

KW - Atractylodis macrocephalae

UR - https://www.scopus.com/pages/publications/57049106343

U2 - 10.1080/14786410801931629

DO - 10.1080/14786410801931629

M3 - 文章

C2 - 19023804

AN - SCOPUS:57049106343

SN - 1478-6419

VL - 22

SP - 1418

EP - 1427

JO - Natural Product Research

JF - Natural Product Research

IS - 16

ER -

Anti-inflammatory components isolated from Atractylodes macrocephala Koidz

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