An efficient, practical synthesis of 2-methoxyestradiol

Minhang Xin; Qidong You; Hua Xiang

doi:10.1016/j.steroids.2009.09.013

An efficient, practical synthesis of 2-methoxyestradiol

Minhang Xin
, Qidong You
, Hua Xiang

China Pharmaceutical University

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

An efficient and practical scheme to synthesize 2-methoxyestradiol has been developed. The key step was the copper-mediated methoxylation using ethyl acetate as a co-catalyst to introduce a methoxyl group. These synthetic procedures of four steps from 17β-estradiol as starting material gave 2-methoxyestradiol with a 61% overall yield.

Original language	English
Pages (from-to)	53-56
Number of pages	4
Journal	Steroids
Volume	75
Issue number	1
DOIs	https://doi.org/10.1016/j.steroids.2009.09.013
State	Published - Jan 2010
Externally published	Yes

Keywords

2-Methoxyestradiol
Co-catalyst
Copper-mediated methoxylation
Ethyl acetate
Synthesis

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10.1016/j.steroids.2009.09.013

Cite this

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title = "An efficient, practical synthesis of 2-methoxyestradiol",

abstract = "An efficient and practical scheme to synthesize 2-methoxyestradiol has been developed. The key step was the copper-mediated methoxylation using ethyl acetate as a co-catalyst to introduce a methoxyl group. These synthetic procedures of four steps from 17β-estradiol as starting material gave 2-methoxyestradiol with a 61\% overall yield.",

keywords = "2-Methoxyestradiol, Co-catalyst, Copper-mediated methoxylation, Ethyl acetate, Synthesis",

author = "Minhang Xin and Qidong You and Hua Xiang",

year = "2010",

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AU - Xin, Minhang

AU - You, Qidong

AU - Xiang, Hua

PY - 2010/1

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N2 - An efficient and practical scheme to synthesize 2-methoxyestradiol has been developed. The key step was the copper-mediated methoxylation using ethyl acetate as a co-catalyst to introduce a methoxyl group. These synthetic procedures of four steps from 17β-estradiol as starting material gave 2-methoxyestradiol with a 61% overall yield.

AB - An efficient and practical scheme to synthesize 2-methoxyestradiol has been developed. The key step was the copper-mediated methoxylation using ethyl acetate as a co-catalyst to introduce a methoxyl group. These synthetic procedures of four steps from 17β-estradiol as starting material gave 2-methoxyestradiol with a 61% overall yield.

KW - 2-Methoxyestradiol

KW - Co-catalyst

KW - Copper-mediated methoxylation

KW - Ethyl acetate

KW - Synthesis

UR - https://www.scopus.com/pages/publications/71849086800

U2 - 10.1016/j.steroids.2009.09.013

DO - 10.1016/j.steroids.2009.09.013

M3 - 文章

C2 - 19835898

AN - SCOPUS:71849086800

SN - 0039-128X

VL - 75

SP - 53

EP - 56

JO - Steroids

JF - Steroids

IS - 1

ER -

An efficient, practical synthesis of 2-methoxyestradiol

Abstract

Keywords

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