An aptameric graphene nanosensor for direct and sensitive vasopressin detection

  • Chao Su
  • , Xuejun Wang
  • , Milan N. Milosavic
  • , Maogang He
  • , Qiao Lin

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This paper presents an aptameric graphene field-effect transistor (FET) nanosensor for direct detection of a low-charged, small molecule arginine vasopressin (AVP). The nanosensor was functionalized with a long chain aptamer to provide large conformation change of aptamer upon the recognition between the aptamer and AVP molecules, yielding appreciable change in conductance of graphene. Experimental results demonstrate the quantification of AVP in a range of 10 pM to 100 nM, yielding a Limit of Detection (LOD) of 1.72 pM.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages487-488
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 22 Oct 201726 Oct 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Country/TerritoryUnited States
CitySavannah
Period22/10/1726/10/17

Keywords

  • Aptamer
  • FET
  • Graphene Nanosensor
  • Vasopressin

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