Abstract
Objective. To investigate the mechanism of tazarotene in active psoriasis vulgaris. Methods. HB-EGF protein in active psoriatic lesions before and 10 days after the treatment of tazarotene was detected by immunohistochemistry. Results. There was nearly no expression of HB-EGF in psoriatic lesions (9.1%), but after the treatment by tazarotene, there was expression of HB-EGF not only in basal layer (95.5%), but also focal expression in suprabasal layers of epidermis (77.3%). Conclusion. Tazarotene inhibit proliferation and induce apoptosis of keratinocytes through upregulating expression of HB-EGF in psoriatic epidermis.
| Original language | English |
|---|---|
| Pages (from-to) | 41-43 |
| Number of pages | 3 |
| Journal | Academic Journal of Xi'an Jiaotong University |
| Volume | 15 |
| Issue number | 1 |
| State | Published - May 2003 |
Keywords
- HB-EGF
- Psoriasis
- Suprabasal epidermis