Air Discharge Plasma-Activated Hydrogels Combined With Nitrogenous Nanographene Oxide Exhibit Enhanced Anticancer Efficacy

Danqi Zhang; Zewei Wang; Zimu Yu; Xixi Jing; Xinwei Lu; Hao Zhang; Jishen Zhang; Dingxin Liu; Cheng Wang; Mingzhe Rong

doi:10.1002/ppap.70080

Air Discharge Plasma-Activated Hydrogels Combined With Nitrogenous Nanographene Oxide Exhibit Enhanced Anticancer Efficacy

Danqi Zhang
, Zewei Wang
, Zimu Yu
, Xixi Jing
, Xinwei Lu
, Hao Zhang
, Jishen Zhang
, Dingxin Liu
, Cheng Wang
, Mingzhe Rong

School of Electrical Engineering

Xi'an Jiaotong University
University of Science and Technology of China

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Cold atmospheric plasma-activated hydrogel (PAH) have proven effective as a novel anticancer method. In this study, air discharge plasma-activated pluronic F127 hydrogel (PAH_PF127) combined with nitrogenous nanographene oxide (GO/N) are proposed for enhancing anticancer efficacy. The results showed that PAH_PF127 could effectively load various reactive oxygen and nitrogen species generated by plasma without adversely affecting the physicochemical properties. In addition, the in vitro results indicated that the PAH_PF127 had an anticancer effect on B16F10 melanoma cells, and the combination treatment reduced cancer cell viability to 49%, compared to 73% for PAH_PF127 and 88% for GO/N alone, and increased intracellular ROS levels by 2.4-fold. These findings highlight the potential of PAH_PF127-GO/N as an innovative platform for enhanced plasma-induced cancer therapy.

Original language	English
Article number	70080
Journal	Plasma Processes and Polymers
Volume	22
Issue number	11
DOIs	https://doi.org/10.1002/ppap.70080
State	Published - Nov 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

anticancer effect
cold atmospheric plasma
nitrogenous nanographene oxide
plasma-activated hydrogels
reactive oxygen and nitrogen species

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10.1002/ppap.70080

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@article{2e91628d4baf4ad799e69a249d70066e,

title = "Air Discharge Plasma-Activated Hydrogels Combined With Nitrogenous Nanographene Oxide Exhibit Enhanced Anticancer Efficacy",

abstract = "Cold atmospheric plasma-activated hydrogel (PAH) have proven effective as a novel anticancer method. In this study, air discharge plasma-activated pluronic F127 hydrogel (PAHPF127) combined with nitrogenous nanographene oxide (GO/N) are proposed for enhancing anticancer efficacy. The results showed that PAHPF127 could effectively load various reactive oxygen and nitrogen species generated by plasma without adversely affecting the physicochemical properties. In addition, the in vitro results indicated that the PAHPF127 had an anticancer effect on B16F10 melanoma cells, and the combination treatment reduced cancer cell viability to 49\%, compared to 73\% for PAHPF127 and 88\% for GO/N alone, and increased intracellular ROS levels by 2.4-fold. These findings highlight the potential of PAHPF127-GO/N as an innovative platform for enhanced plasma-induced cancer therapy.",

keywords = "anticancer effect, cold atmospheric plasma, nitrogenous nanographene oxide, plasma-activated hydrogels, reactive oxygen and nitrogen species",

author = "Danqi Zhang and Zewei Wang and Zimu Yu and Xixi Jing and Xinwei Lu and Hao Zhang and Jishen Zhang and Dingxin Liu and Cheng Wang and Mingzhe Rong",

note = "Publisher Copyright: {\textcopyright} 2025 Wiley-VCH GmbH.",

year = "2025",

month = nov,

doi = "10.1002/ppap.70080",

language = "英语",

volume = "22",

journal = "Plasma Processes and Polymers",

issn = "1612-8850",

publisher = "Wiley-VCH Verlag",

number = "11",

}

TY - JOUR

T1 - Air Discharge Plasma-Activated Hydrogels Combined With Nitrogenous Nanographene Oxide Exhibit Enhanced Anticancer Efficacy

AU - Zhang, Danqi

AU - Wang, Zewei

AU - Yu, Zimu

AU - Jing, Xixi

AU - Lu, Xinwei

AU - Zhang, Hao

AU - Zhang, Jishen

AU - Liu, Dingxin

AU - Wang, Cheng

AU - Rong, Mingzhe

PY - 2025/11

Y1 - 2025/11

N2 - Cold atmospheric plasma-activated hydrogel (PAH) have proven effective as a novel anticancer method. In this study, air discharge plasma-activated pluronic F127 hydrogel (PAHPF127) combined with nitrogenous nanographene oxide (GO/N) are proposed for enhancing anticancer efficacy. The results showed that PAHPF127 could effectively load various reactive oxygen and nitrogen species generated by plasma without adversely affecting the physicochemical properties. In addition, the in vitro results indicated that the PAHPF127 had an anticancer effect on B16F10 melanoma cells, and the combination treatment reduced cancer cell viability to 49%, compared to 73% for PAHPF127 and 88% for GO/N alone, and increased intracellular ROS levels by 2.4-fold. These findings highlight the potential of PAHPF127-GO/N as an innovative platform for enhanced plasma-induced cancer therapy.

AB - Cold atmospheric plasma-activated hydrogel (PAH) have proven effective as a novel anticancer method. In this study, air discharge plasma-activated pluronic F127 hydrogel (PAHPF127) combined with nitrogenous nanographene oxide (GO/N) are proposed for enhancing anticancer efficacy. The results showed that PAHPF127 could effectively load various reactive oxygen and nitrogen species generated by plasma without adversely affecting the physicochemical properties. In addition, the in vitro results indicated that the PAHPF127 had an anticancer effect on B16F10 melanoma cells, and the combination treatment reduced cancer cell viability to 49%, compared to 73% for PAHPF127 and 88% for GO/N alone, and increased intracellular ROS levels by 2.4-fold. These findings highlight the potential of PAHPF127-GO/N as an innovative platform for enhanced plasma-induced cancer therapy.

KW - anticancer effect

KW - cold atmospheric plasma

KW - nitrogenous nanographene oxide

KW - plasma-activated hydrogels

KW - reactive oxygen and nitrogen species

UR - https://www.scopus.com/pages/publications/105017884778

U2 - 10.1002/ppap.70080

DO - 10.1002/ppap.70080

M3 - 文章

AN - SCOPUS:105017884778

SN - 1612-8850

VL - 22

JO - Plasma Processes and Polymers

JF - Plasma Processes and Polymers

IS - 11

M1 - 70080

ER -

Air Discharge Plasma-Activated Hydrogels Combined With Nitrogenous Nanographene Oxide Exhibit Enhanced Anticancer Efficacy

Abstract

UN SDGs

Keywords

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