Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus

Lin Kong; Rongyuan Zhang; Junyi Gong; Huan Wang; Lingyu Zhai; Dongfeng Dang; Qian Liu; Zheng Zhao; Ben Zhong Tang

doi:10.1039/d4cc01022a

Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus

Lin Kong
, Rongyuan Zhang
, Junyi Gong
, Huan Wang
, Lingyu Zhai
, Dongfeng Dang
, Qian Liu
, Zheng Zhao
, Ben Zhong Tang

School of Chemistry

Anhui University
The Chinese University of Hong Kong, Shenzhen
Tianjin First Central Hospital
Hong Kong University of Science and Technology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A cationic aggregation-induced emission photosensitizer (AIE-PS) MNNPyBB has been reported to have antibacterial effects against both Gram-positive and Gram-negative bacteria. The bacterial kill mechanism has been investigated and elucidated. In a methicillin-resistant Staphylococcus aureus subcutaneous infection model, wound closure has been achieved with normal re-epithelialization and preserved skin morphology.

Original language	English
Pages (from-to)	5960-5963
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	46
DOIs	https://doi.org/10.1039/d4cc01022a
State	Published - 7 May 2024

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10.1039/d4cc01022a

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title = "Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus",

abstract = "A cationic aggregation-induced emission photosensitizer (AIE-PS) MNNPyBB has been reported to have antibacterial effects against both Gram-positive and Gram-negative bacteria. The bacterial kill mechanism has been investigated and elucidated. In a methicillin-resistant Staphylococcus aureus subcutaneous infection model, wound closure has been achieved with normal re-epithelialization and preserved skin morphology.",

author = "Lin Kong and Rongyuan Zhang and Junyi Gong and Huan Wang and Lingyu Zhai and Dongfeng Dang and Qian Liu and Zheng Zhao and Tang, \{Ben Zhong\}",

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doi = "10.1039/d4cc01022a",

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T1 - Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus

AU - Kong, Lin

AU - Zhang, Rongyuan

AU - Gong, Junyi

AU - Wang, Huan

AU - Zhai, Lingyu

AU - Dang, Dongfeng

AU - Liu, Qian

AU - Zhao, Zheng

AU - Tang, Ben Zhong

PY - 2024/5/7

Y1 - 2024/5/7

N2 - A cationic aggregation-induced emission photosensitizer (AIE-PS) MNNPyBB has been reported to have antibacterial effects against both Gram-positive and Gram-negative bacteria. The bacterial kill mechanism has been investigated and elucidated. In a methicillin-resistant Staphylococcus aureus subcutaneous infection model, wound closure has been achieved with normal re-epithelialization and preserved skin morphology.

AB - A cationic aggregation-induced emission photosensitizer (AIE-PS) MNNPyBB has been reported to have antibacterial effects against both Gram-positive and Gram-negative bacteria. The bacterial kill mechanism has been investigated and elucidated. In a methicillin-resistant Staphylococcus aureus subcutaneous infection model, wound closure has been achieved with normal re-epithelialization and preserved skin morphology.

UR - https://www.scopus.com/pages/publications/85193583803

U2 - 10.1039/d4cc01022a

DO - 10.1039/d4cc01022a

M3 - 文章

C2 - 38767007

AN - SCOPUS:85193583803

SN - 1359-7345

VL - 60

SP - 5960

EP - 5963

JO - Chemical Communications

JF - Chemical Communications

IS - 46

ER -

Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus

Abstract

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