Abstract
Oct4 gene, a member of POU transcription factor family, is expressed in embryonic stem (ES) cells and embryonic carcinoma (EC) cells, but not in cells of differentiated tissues. It plays a critical role in maintaining pluripotent and self-renewing state of embryonic stem cells. The molecular structure, function, regulation passageway and the relationship with tumors of Oct4 gene have been briefly reviewed.
| Original language | English |
|---|---|
| Pages (from-to) | 521-526 |
| Number of pages | 6 |
| Journal | Journal of Xi'an Jiaotong University (Medical Sciences) |
| Volume | 31 |
| Issue number | 5 |
| State | Published - Sep 2010 |
Keywords
- Oct4
- POU5F1
- Regulation passageway
- Tumor
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