Advances in research on molecular mechanisms for the proliferation of pulmonary artery smooth muscle cells and their intervention

Pulmonary artery hypertension (PAH) is a common clinical syndrome. The over-proliferation of pulmonary arterial smooth muscle cells (PASMCs) is a hallmark of pulmonary vascular remodeling which is a critical and fundamental pathogenesis in the development of a variety of pulmonary artery hypertension. Here, we review the advances in studies on signaling transduction pathways mediating the proliferation of PASMCs and also introduce the existing approaches in inhibiting their proliferation and relevant research advances.