TY - JOUR
T1 - Acute promyelocytic leukemia transformation in a patient with aplastic anemia
T2 - A case report with literature review
AU - Wang, Xiaoning
AU - Yuan, Tingting
AU - Wang, Wenjuan
AU - Chen, Limei
AU - Wang, Huaiyu
AU - Liu, Yalin
N1 - Publisher Copyright:
© 2015 E-Century Publishing Corporation. All rights reserved.
PY - 2015/11/30
Y1 - 2015/11/30
N2 - Aplastic anemia (AA) is a hematological disorder presenting with pancytopenia in peripheral blood and hypocellularity in bone marrow. AA patients with immunosuppressive therapy and granulocyte colony-stimulating factor treatment have a risk of development of acute leukemia including acute myeloid leukemia (M0, M1, M2, M4, M5, M6) and acute lymphoblastic leukemia. However, AA with transformation to acute promyelocytic leukemia (APL) has never been reported. Here, we reported a patient initially diagnosed with AA. while 19 years later, PML/RAR αfusion gene were detected and the patient was eventually diagnosed as APL. The diagnosis and management of this interesting case are discussed.
AB - Aplastic anemia (AA) is a hematological disorder presenting with pancytopenia in peripheral blood and hypocellularity in bone marrow. AA patients with immunosuppressive therapy and granulocyte colony-stimulating factor treatment have a risk of development of acute leukemia including acute myeloid leukemia (M0, M1, M2, M4, M5, M6) and acute lymphoblastic leukemia. However, AA with transformation to acute promyelocytic leukemia (APL) has never been reported. Here, we reported a patient initially diagnosed with AA. while 19 years later, PML/RAR αfusion gene were detected and the patient was eventually diagnosed as APL. The diagnosis and management of this interesting case are discussed.
KW - Acute promyelocytic leukemia
KW - Aplastic anemia
KW - Immunosuppressive therapy
UR - https://www.scopus.com/pages/publications/84954201737
M3 - 文章
AN - SCOPUS:84954201737
SN - 1940-5901
VL - 8
SP - 20675
EP - 20678
JO - International Journal of Clinical and Experimental Medicine
JF - International Journal of Clinical and Experimental Medicine
IS - 11
ER -