A visualization quality evaluation method for multiple sequence alignments

  • Hongbin Lee
  • , Bo Wang
  • , Xiaoming Wu
  • , Yonggang Liu
  • , Wei Gao
  • , Huili Li
  • , Xu Wang
  • , Feng He

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Multiple sequence alignments (MSA) method is basic way for the analysis of biology sequences. As dozens of MSA algorithms appears, reasonable and effective quality evaluation method is necessary. Gap-insertion is common phenomenon after MSA, and should be an important factor to evaluate whether MSA is successful. A new MSA score evaluation method was introduced in this paper, which was based on the combination of both row distance of letters and column consensus of sequences. It can be used to evaluate the quality of MSA in the global and local justly and effectively. At same time, two formulas for assessing the distance of different MSA algorithms were derived.

Original languageEnglish
Title of host publication5th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2011
DOIs
StatePublished - 2011
Event5th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2011 - Wuhan, China
Duration: 10 May 201112 May 2011

Publication series

Name5th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2011

Conference

Conference5th International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2011
Country/TerritoryChina
CityWuhan
Period10/05/1112/05/11

Keywords

  • Gap insertion
  • MSA
  • Quality evaluation
  • Visualization

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