TY - JOUR
T1 - A potential calcium antagonist and its antihypertensive effects
AU - Zhang, Yan
AU - Cao, Yanjun
AU - Wang, Qunli
AU - Zheng, Lei
AU - Zhang, Jie
AU - He, Langchong
PY - 2011/10
Y1 - 2011/10
N2 - Imperatorin (Imp) as a hypotensive active ingredient, its hypotensive effect was evaluated in the SHRs, its calcium antagonism and affinity to L-type calcium channel was also confirmed. The results showed that the blood pressure was decreased in the SHRs treated with Imp, the aortic ring was relaxed with Imp, L-type calcium channel currents and intracellular calcium free ion rise was nearly disappeared when adding Imp. In addition, Imp displayed a chromatographic peak similar to nitrendipine and verapamil by the cell membrane chromatography, same results from protein-drug docking approaches. Hence, Imp target the L-type calcium channel, and may be used as a novel antihypertensive drug.
AB - Imperatorin (Imp) as a hypotensive active ingredient, its hypotensive effect was evaluated in the SHRs, its calcium antagonism and affinity to L-type calcium channel was also confirmed. The results showed that the blood pressure was decreased in the SHRs treated with Imp, the aortic ring was relaxed with Imp, L-type calcium channel currents and intracellular calcium free ion rise was nearly disappeared when adding Imp. In addition, Imp displayed a chromatographic peak similar to nitrendipine and verapamil by the cell membrane chromatography, same results from protein-drug docking approaches. Hence, Imp target the L-type calcium channel, and may be used as a novel antihypertensive drug.
KW - Calcium antagonists
KW - Imperatorin (Imp)
KW - L-type calcium channel
KW - Spontaneously hypertensive rats (SHRs)
KW - Vascular smooth muscle (VSM)
UR - https://www.scopus.com/pages/publications/80052147634
U2 - 10.1016/j.fitote.2011.05.016
DO - 10.1016/j.fitote.2011.05.016
M3 - 文章
C2 - 21679750
AN - SCOPUS:80052147634
SN - 0367-326X
VL - 82
SP - 988
EP - 996
JO - Fitoterapia
JF - Fitoterapia
IS - 7
ER -