A photovoltage-based integrated sensor for nephrotoxicity evaluation under drug stimulation

J. Wang; H. Yu; H. Cai; L. P. Du; Q. J. Liu; P. Wang

doi:10.1109/TRANSDUCERS.2011.5969276

A photovoltage-based integrated sensor for nephrotoxicity evaluation under drug stimulation

J. Wang
, H. Yu
, H. Cai
, L. P. Du
, Q. J. Liu
, P. Wang

Key Lab of the Ministry of Education for Process Control and Efficiency Egineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

A monolithically integrated sensor based on photovoltage technique is developed for kidney metabolism detection under drug toxicity. The sensor utilizes the light-addressable potentiometric sensor with an electrolyte-insulator-semiconductor (EIS) structure for measuring cellular metabolic rate, and a gold metal layer is deposited on partial surface of silicon dioxide for extracellular redox (reduction-oxidation) potential detection. The neonatal rat's kidney cells are confined to a flow chamber with a volume of 50 μl, in which the constructed sensor continuously monitoring the rate of acid metabolites, and the redox potential in extracellular microenvironment. The synthesis parameters detected reflect the cellular metabolic and active condition after drug stimulation, which demonstrates the potentials for nephrotoxicity evaluation and preclinical drug screening.

Original language	English
Title of host publication	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Pages	2122-2125
Number of pages	4
DOIs	https://doi.org/10.1109/TRANSDUCERS.2011.5969276
State	Published - 2011
Externally published	Yes
Event	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 - Beijing, China Duration: 5 Jun 2011 → 9 Jun 2011

Publication series

Name	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11

Conference

Conference	2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11
Country/Territory	China
City	Beijing
Period	5/06/11 → 9/06/11

Keywords

Drug screening
Integrated chemical sensor
Photovoltage technique

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10.1109/TRANSDUCERS.2011.5969276

Cite this

Wang, J., Yu, H., Cai, H., Du, L. P., Liu, Q. J., & Wang, P. (2011). A photovoltage-based integrated sensor for nephrotoxicity evaluation under drug stimulation. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 (pp. 2122-2125). Article 5969276 (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11). https://doi.org/10.1109/TRANSDUCERS.2011.5969276

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title = "A photovoltage-based integrated sensor for nephrotoxicity evaluation under drug stimulation",

abstract = "A monolithically integrated sensor based on photovoltage technique is developed for kidney metabolism detection under drug toxicity. The sensor utilizes the light-addressable potentiometric sensor with an electrolyte-insulator-semiconductor (EIS) structure for measuring cellular metabolic rate, and a gold metal layer is deposited on partial surface of silicon dioxide for extracellular redox (reduction-oxidation) potential detection. The neonatal rat's kidney cells are confined to a flow chamber with a volume of 50 μl, in which the constructed sensor continuously monitoring the rate of acid metabolites, and the redox potential in extracellular microenvironment. The synthesis parameters detected reflect the cellular metabolic and active condition after drug stimulation, which demonstrates the potentials for nephrotoxicity evaluation and preclinical drug screening.",

keywords = "Drug screening, Integrated chemical sensor, Photovoltage technique",

author = "J. Wang and H. Yu and H. Cai and Du, \{L. P.\} and Liu, \{Q. J.\} and P. Wang",

year = "2011",

doi = "10.1109/TRANSDUCERS.2011.5969276",

language = "英语",

isbn = "9781457701573",

series = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",

pages = "2122--2125",

booktitle = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11",

note = "2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11 ; Conference date: 05-06-2011 Through 09-06-2011",

}

Wang, J, Yu, H, Cai, H, Du, LP, Liu, QJ & Wang, P 2011, A photovoltage-based integrated sensor for nephrotoxicity evaluation under drug stimulation. in 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11., 5969276, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, pp. 2122-2125, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, Beijing, China, 5/06/11. https://doi.org/10.1109/TRANSDUCERS.2011.5969276

A photovoltage-based integrated sensor for nephrotoxicity evaluation under drug stimulation. / Wang, J.; Yu, H.; Cai, H. et al.
2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. p. 2122-2125 5969276 (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Yu, H.

AU - Cai, H.

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AU - Liu, Q. J.

AU - Wang, P.

PY - 2011

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N2 - A monolithically integrated sensor based on photovoltage technique is developed for kidney metabolism detection under drug toxicity. The sensor utilizes the light-addressable potentiometric sensor with an electrolyte-insulator-semiconductor (EIS) structure for measuring cellular metabolic rate, and a gold metal layer is deposited on partial surface of silicon dioxide for extracellular redox (reduction-oxidation) potential detection. The neonatal rat's kidney cells are confined to a flow chamber with a volume of 50 μl, in which the constructed sensor continuously monitoring the rate of acid metabolites, and the redox potential in extracellular microenvironment. The synthesis parameters detected reflect the cellular metabolic and active condition after drug stimulation, which demonstrates the potentials for nephrotoxicity evaluation and preclinical drug screening.

AB - A monolithically integrated sensor based on photovoltage technique is developed for kidney metabolism detection under drug toxicity. The sensor utilizes the light-addressable potentiometric sensor with an electrolyte-insulator-semiconductor (EIS) structure for measuring cellular metabolic rate, and a gold metal layer is deposited on partial surface of silicon dioxide for extracellular redox (reduction-oxidation) potential detection. The neonatal rat's kidney cells are confined to a flow chamber with a volume of 50 μl, in which the constructed sensor continuously monitoring the rate of acid metabolites, and the redox potential in extracellular microenvironment. The synthesis parameters detected reflect the cellular metabolic and active condition after drug stimulation, which demonstrates the potentials for nephrotoxicity evaluation and preclinical drug screening.

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KW - Integrated chemical sensor

KW - Photovoltage technique

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M3 - 会议稿件

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ER -

Wang J, Yu H, Cai H, Du LP, Liu QJ, Wang P. A photovoltage-based integrated sensor for nephrotoxicity evaluation under drug stimulation. In 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11. 2011. p. 2122-2125. 5969276. (2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11). doi: 10.1109/TRANSDUCERS.2011.5969276

A photovoltage-based integrated sensor for nephrotoxicity evaluation under drug stimulation

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