TY - GEN
T1 - A paper-based electrochemical impedance spectrometry biosensor integrating zinc oxide nanowires for ultrasensitive, label-free immunoassays
AU - Li, X.
AU - Liu, X.
N1 - Publisher Copyright:
© 15CBMS-0001.
PY - 2015
Y1 - 2015
N2 - This paper reports the first paper-based electrochemical impedance spectrometry (EIS) biosensor, integrating in-situ synthesized zinc oxide nanowires, for ultrasensitive, label-free immunoassays. Using rabbit-IgG in PBS, we demonstrate a limit of detection of 60 fg/mL, 100-fold better than those of previous paper-based biosensors. The ultrasensitive performance is attributed to: (i) the high surface-to-volume ratios and high sensitivity of zinc oxide nanowires; and (ii) the high specificity of EIS biosensing. The label-free EIS mechanism also renders simpler sensing operations.
AB - This paper reports the first paper-based electrochemical impedance spectrometry (EIS) biosensor, integrating in-situ synthesized zinc oxide nanowires, for ultrasensitive, label-free immunoassays. Using rabbit-IgG in PBS, we demonstrate a limit of detection of 60 fg/mL, 100-fold better than those of previous paper-based biosensors. The ultrasensitive performance is attributed to: (i) the high surface-to-volume ratios and high sensitivity of zinc oxide nanowires; and (ii) the high specificity of EIS biosensing. The label-free EIS mechanism also renders simpler sensing operations.
KW - Biosensing
KW - Electrochemical impedance spectrometry
KW - Microfluidic paper-based analytical device
KW - Zinc oxide nanowire
UR - https://www.scopus.com/pages/publications/84983234022
M3 - 会议稿件
AN - SCOPUS:84983234022
T3 - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
SP - 44
EP - 46
BT - MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PB - Chemical and Biological Microsystems Society
T2 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
Y2 - 25 October 2015 through 29 October 2015
ER -