A novel gastric ulcer model in rats using filter paper with acetic acid

Siyuan Dong; Xudong Wang; Yixin Liu; Lu Qiao; Qiong Xue; Yixin Zhou; Zhao Xu; Qun Chen; Chen Chen; Na Liu; Jinhai Wang

doi:10.1371/journal.pone.0319096

A novel gastric ulcer model in rats using filter paper with acetic acid

Siyuan Dong
, Xudong Wang
, Yixin Liu
, Lu Qiao
, Qiong Xue
, Yixin Zhou
, Zhao Xu
, Qun Chen
, Chen Chen
, Na Liu
, Jinhai Wang

Xi'an Jiaotong University
Xi'an University of Science and Technology
The Second Affiliated Hospital of Xi'an Jiaotong University
University of Queensland

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Gastric ulcer animal models are essential for research, but conventional acetic acid-based methods are limited by technical complexity, prolonged modeling duration, and poor applicability for solid anti-ulcer drug testing. This study described a novel and simplified method for inducing gastric ulcers in rats using filter paper imbued with acetic acid. The method provided consistent ulcer formation with uniform size and shape, allowing for targeted drug efficacy testing. Results indicated that the 75% acetic acid concentration yielded the most clinically relevant gastric ulcer model, completed ulcer forming within a day and healing visible after seven days. In conclusion, this model closely replicates human gastric ulcers and is well-suited for preclinical testing of anti-ulcer drugs.

Original language	English
Article number	e0319096
Journal	PLoS ONE
Volume	20
Issue number	4 April
DOIs	https://doi.org/10.1371/journal.pone.0319096
State	Published - Apr 2025
Externally published	Yes

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10.1371/journal.pone.0319096

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title = "A novel gastric ulcer model in rats using filter paper with acetic acid",

abstract = "Gastric ulcer animal models are essential for research, but conventional acetic acid-based methods are limited by technical complexity, prolonged modeling duration, and poor applicability for solid anti-ulcer drug testing. This study described a novel and simplified method for inducing gastric ulcers in rats using filter paper imbued with acetic acid. The method provided consistent ulcer formation with uniform size and shape, allowing for targeted drug efficacy testing. Results indicated that the 75\% acetic acid concentration yielded the most clinically relevant gastric ulcer model, completed ulcer forming within a day and healing visible after seven days. In conclusion, this model closely replicates human gastric ulcers and is well-suited for preclinical testing of anti-ulcer drugs.",

author = "Siyuan Dong and Xudong Wang and Yixin Liu and Lu Qiao and Qiong Xue and Yixin Zhou and Zhao Xu and Qun Chen and Chen Chen and Na Liu and Jinhai Wang",

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doi = "10.1371/journal.pone.0319096",

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TY - JOUR

T1 - A novel gastric ulcer model in rats using filter paper with acetic acid

AU - Dong, Siyuan

AU - Wang, Xudong

AU - Liu, Yixin

AU - Qiao, Lu

AU - Xue, Qiong

AU - Zhou, Yixin

AU - Xu, Zhao

AU - Chen, Qun

AU - Chen, Chen

AU - Liu, Na

AU - Wang, Jinhai

N1 - Publisher Copyright: © 2025 Dong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2025/4

Y1 - 2025/4

N2 - Gastric ulcer animal models are essential for research, but conventional acetic acid-based methods are limited by technical complexity, prolonged modeling duration, and poor applicability for solid anti-ulcer drug testing. This study described a novel and simplified method for inducing gastric ulcers in rats using filter paper imbued with acetic acid. The method provided consistent ulcer formation with uniform size and shape, allowing for targeted drug efficacy testing. Results indicated that the 75% acetic acid concentration yielded the most clinically relevant gastric ulcer model, completed ulcer forming within a day and healing visible after seven days. In conclusion, this model closely replicates human gastric ulcers and is well-suited for preclinical testing of anti-ulcer drugs.

AB - Gastric ulcer animal models are essential for research, but conventional acetic acid-based methods are limited by technical complexity, prolonged modeling duration, and poor applicability for solid anti-ulcer drug testing. This study described a novel and simplified method for inducing gastric ulcers in rats using filter paper imbued with acetic acid. The method provided consistent ulcer formation with uniform size and shape, allowing for targeted drug efficacy testing. Results indicated that the 75% acetic acid concentration yielded the most clinically relevant gastric ulcer model, completed ulcer forming within a day and healing visible after seven days. In conclusion, this model closely replicates human gastric ulcers and is well-suited for preclinical testing of anti-ulcer drugs.

UR - https://www.scopus.com/pages/publications/105002816065

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DO - 10.1371/journal.pone.0319096

M3 - 文章

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VL - 20

JO - PLoS ONE

JF - PLoS ONE

IS - 4 April

M1 - e0319096

ER -

A novel gastric ulcer model in rats using filter paper with acetic acid

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