A novel and facile synthetic approach for tasigna

Xiaoyan Pan; Wen Lu; Pengfei Li; Fang Wang; Chen Wang; Zhigang Hu; Jie Zhang

doi:10.2174/157340612802084207

A novel and facile synthetic approach for tasigna

Xiaoyan Pan
, Wen Lu
, Pengfei Li
, Fang Wang
, Chen Wang
, Zhigang Hu
, Jie Zhang

Health Science Center

Xi'an Jiaotong University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40β). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.

Original language	English
Pages (from-to)	985-989
Number of pages	5
Journal	Medicinal Chemistry
Volume	8
Issue number	5
DOIs	https://doi.org/10.2174/157340612802084207
State	Published - Sep 2012

Keywords

Bcr-Abl kinase inhibitor
Condensation
Cu-catalyzed N-arylation
Facile synthesis
Tasigna

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10.2174/157340612802084207

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abstract = "A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40β). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.",

keywords = "Bcr-Abl kinase inhibitor, Condensation, Cu-catalyzed N-arylation, Facile synthesis, Tasigna",

author = "Xiaoyan Pan and Wen Lu and Pengfei Li and Fang Wang and Chen Wang and Zhigang Hu and Jie Zhang",

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T1 - A novel and facile synthetic approach for tasigna

AU - Pan, Xiaoyan

AU - Lu, Wen

AU - Li, Pengfei

AU - Wang, Fang

AU - Wang, Chen

AU - Hu, Zhigang

AU - Zhang, Jie

PY - 2012/9

Y1 - 2012/9

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AB - A simple and practical synthetic approach for tasigna was described here in six steps with high yield (40β). All of the intermediates and final target compound were isolated cleanly in high yield without a need for chromatographic purification. Significantly, the facile synthetic route proposed in this work has the characteristics of mild synthetic conditions, inexpensive reagents, high yield and simple operation.

KW - Bcr-Abl kinase inhibitor

KW - Condensation

KW - Cu-catalyzed N-arylation

KW - Facile synthesis

KW - Tasigna

UR - https://www.scopus.com/pages/publications/84865706204

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DO - 10.2174/157340612802084207

M3 - 文章

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JO - Medicinal Chemistry

JF - Medicinal Chemistry

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ER -

A novel and facile synthetic approach for tasigna

Abstract

Keywords

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