A new coumarin isolated from the roots of Heracleum dissectum Ledeb

A new coumarin named (9 R, 10 R)-9, 10-dihydro-10-hydroxy-9-methoxy-bergapten (1) and 13 known compounds (2–14) were isolated from the roots of Heracleum dissectum Ledeb., in which compounds (2–13) were obtained from H. dissectum for the first time. Their structures were illuminated by HR-ESI MS, 1 D and 2 D NMR, optical rotation and comparison with literatures. All compounds were evaluated against hepatocellular carcinoma HepG2 cell lines and the results showed that candinol C (8) had moderate cytotoxic activity against HepG2 cells with IC₅₀ value at 57.6 ± 1.1 µM.