A fluorescence sensing platform with the MnO2 nanosheets as an effective oxidant for glutathione detection

Cuiping Yao; Jing Wang; Aixian Zheng; Lingjie Wu; Xiaolong Zhang; Xiaolong Liu

doi:10.1016/j.snb.2017.05.136

A fluorescence sensing platform with the MnO₂ nanosheets as an effective oxidant for glutathione detection

Cuiping Yao
, Jing Wang
, Aixian Zheng
, Lingjie Wu
, Xiaolong Zhang
, Xiaolong Liu

School of Life Science and Technology (SLST)

Fujian Medical University

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Herein, a sensitive, selective, rapid and cost-effective fluorescence sensing platform has been designed for the detection of glutathione (GSH). In this platform, the manganese dioxide (MnO₂) nanosheets served as both oxidant, which could effectively oxidize o-phenylenediamine (OPDA) to produce fluorescence for highly sensitive detection, and recognition element. When GSH was introduced, the MnO₂ nanosheets were reduced to Mn²⁺, which inhibited the formation of fluorescent oxidation products of OPDA. Under optimal conditions, the MnO₂-OPDA sensing platform showed very sensitive response to GSH in the range of 10 nM–40 μM. The detection limit of GSH reached as low as 10 nM. The high selectivity of inhibition of fluorescent product formation by GSH allows this platform to be used for detecting GSH in practical biological samples (such as cell extracts).

Original language	English
Pages (from-to)	30-36
Number of pages	7
Journal	Sensors and Actuators B: Chemical
Volume	252
DOIs	https://doi.org/10.1016/j.snb.2017.05.136
State	Published - Nov 2017

Keywords

Glutathione
Manganese dioxide nanosheets
O-phenylenediamine
Oxidation
Redox reaction

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10.1016/j.snb.2017.05.136

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title = "A fluorescence sensing platform with the MnO2 nanosheets as an effective oxidant for glutathione detection",

abstract = "Herein, a sensitive, selective, rapid and cost-effective fluorescence sensing platform has been designed for the detection of glutathione (GSH). In this platform, the manganese dioxide (MnO2) nanosheets served as both oxidant, which could effectively oxidize o-phenylenediamine (OPDA) to produce fluorescence for highly sensitive detection, and recognition element. When GSH was introduced, the MnO2 nanosheets were reduced to Mn2+, which inhibited the formation of fluorescent oxidation products of OPDA. Under optimal conditions, the MnO2-OPDA sensing platform showed very sensitive response to GSH in the range of 10 nM{\textendash}40 μM. The detection limit of GSH reached as low as 10 nM. The high selectivity of inhibition of fluorescent product formation by GSH allows this platform to be used for detecting GSH in practical biological samples (such as cell extracts).",

keywords = "Glutathione, Manganese dioxide nanosheets, O-phenylenediamine, Oxidation, Redox reaction",

author = "Cuiping Yao and Jing Wang and Aixian Zheng and Lingjie Wu and Xiaolong Zhang and Xiaolong Liu",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier B.V.",

year = "2017",

month = nov,

doi = "10.1016/j.snb.2017.05.136",

language = "英语",

volume = "252",

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TY - JOUR

T1 - A fluorescence sensing platform with the MnO2 nanosheets as an effective oxidant for glutathione detection

AU - Yao, Cuiping

AU - Wang, Jing

AU - Zheng, Aixian

AU - Wu, Lingjie

AU - Zhang, Xiaolong

AU - Liu, Xiaolong

PY - 2017/11

Y1 - 2017/11

N2 - Herein, a sensitive, selective, rapid and cost-effective fluorescence sensing platform has been designed for the detection of glutathione (GSH). In this platform, the manganese dioxide (MnO2) nanosheets served as both oxidant, which could effectively oxidize o-phenylenediamine (OPDA) to produce fluorescence for highly sensitive detection, and recognition element. When GSH was introduced, the MnO2 nanosheets were reduced to Mn2+, which inhibited the formation of fluorescent oxidation products of OPDA. Under optimal conditions, the MnO2-OPDA sensing platform showed very sensitive response to GSH in the range of 10 nM–40 μM. The detection limit of GSH reached as low as 10 nM. The high selectivity of inhibition of fluorescent product formation by GSH allows this platform to be used for detecting GSH in practical biological samples (such as cell extracts).

AB - Herein, a sensitive, selective, rapid and cost-effective fluorescence sensing platform has been designed for the detection of glutathione (GSH). In this platform, the manganese dioxide (MnO2) nanosheets served as both oxidant, which could effectively oxidize o-phenylenediamine (OPDA) to produce fluorescence for highly sensitive detection, and recognition element. When GSH was introduced, the MnO2 nanosheets were reduced to Mn2+, which inhibited the formation of fluorescent oxidation products of OPDA. Under optimal conditions, the MnO2-OPDA sensing platform showed very sensitive response to GSH in the range of 10 nM–40 μM. The detection limit of GSH reached as low as 10 nM. The high selectivity of inhibition of fluorescent product formation by GSH allows this platform to be used for detecting GSH in practical biological samples (such as cell extracts).

KW - Glutathione

KW - Manganese dioxide nanosheets

KW - O-phenylenediamine

KW - Oxidation

KW - Redox reaction

UR - https://www.scopus.com/pages/publications/85020029408

U2 - 10.1016/j.snb.2017.05.136

DO - 10.1016/j.snb.2017.05.136

M3 - 文章

AN - SCOPUS:85020029408

SN - 0925-4005

VL - 252

SP - 30

EP - 36

JO - Sensors and Actuators B: Chemical

JF - Sensors and Actuators B: Chemical

ER -

A fluorescence sensing platform with the MnO₂ nanosheets as an effective oxidant for glutathione detection

Abstract

Keywords

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