A conjugated polymer fluorescent sensor for continuous identification of copper(II) and pyrophosphate in blood serum and synovial fluid

Mingming Guan; Chunling Xu; Jiahua Ma; Ting Yang; Jilin Liu; Guodong Feng

doi:10.2116/analsci.18P576

A conjugated polymer fluorescent sensor for continuous identification of copper(II) and pyrophosphate in blood serum and synovial fluid

Mingming Guan
, Chunling Xu
, Jiahua Ma
, Ting Yang
, Jilin Liu
, Guodong Feng

Jilin University
Southwest University of Science and Technology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

A novel "on-off-on" super-sensitive conjugated polymer fluorescence sensor (PPE-DPA) was developed and it was applied to realize the continuous recognition of Cu²⁺ and pyrophosphate (PPi). The fluorescence intensity decreased linearly with the change of Cu²⁺ from 0.05 to 5.0 μmol L^-1 and the limit of detection was 24 nmol L^-1. The fluorescence intensity was linearly enhanced with the increase of PPi from 0.5 to 12.0 μmol L^-1 and the limit of detection was 230 nmol L^-1. In addition, this method was applied to detect PPi in the blood serum and synovial fluid of patients with arthritis and satisfactory results were obtained. Thus, the PPE-DPA is not only an effective tool for detecting Cu²⁺ and PPi in samples, but also presents a potential way to diagnose arthritis.

Original language	English
Pages (from-to)	625-630
Number of pages	6
Journal	Analytical Sciences
Volume	35
Issue number	6
DOIs	https://doi.org/10.2116/analsci.18P576
State	Published - 2019
Externally published	Yes

Keywords

Blood serum
Conjugated polymer
Cu
Fluorescence sensor
Pyrophosphate
Synovial fluid

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10.2116/analsci.18P576

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@article{78b606e4cd8b4105928f957cb7ec57ec,

title = "A conjugated polymer fluorescent sensor for continuous identification of copper(II) and pyrophosphate in blood serum and synovial fluid",

abstract = "A novel {"}on-off-on{"} super-sensitive conjugated polymer fluorescence sensor (PPE-DPA) was developed and it was applied to realize the continuous recognition of Cu2+ and pyrophosphate (PPi). The fluorescence intensity decreased linearly with the change of Cu2+ from 0.05 to 5.0 μmol L-1 and the limit of detection was 24 nmol L-1. The fluorescence intensity was linearly enhanced with the increase of PPi from 0.5 to 12.0 μmol L-1 and the limit of detection was 230 nmol L-1. In addition, this method was applied to detect PPi in the blood serum and synovial fluid of patients with arthritis and satisfactory results were obtained. Thus, the PPE-DPA is not only an effective tool for detecting Cu2+ and PPi in samples, but also presents a potential way to diagnose arthritis.",

keywords = "Blood serum, Conjugated polymer, Cu, Fluorescence sensor, Pyrophosphate, Synovial fluid",

author = "Mingming Guan and Chunling Xu and Jiahua Ma and Ting Yang and Jilin Liu and Guodong Feng",

note = "Publisher Copyright: {\textcopyright} The Japan Society for Analytical Chemistry.",

year = "2019",

doi = "10.2116/analsci.18P576",

language = "英语",

volume = "35",

pages = "625--630",

journal = "Analytical Sciences",

issn = "0910-6340",

publisher = "Springer International Publishing AG",

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}

TY - JOUR

T1 - A conjugated polymer fluorescent sensor for continuous identification of copper(II) and pyrophosphate in blood serum and synovial fluid

AU - Guan, Mingming

AU - Xu, Chunling

AU - Ma, Jiahua

AU - Yang, Ting

AU - Liu, Jilin

AU - Feng, Guodong

N1 - Publisher Copyright: © The Japan Society for Analytical Chemistry.

PY - 2019

Y1 - 2019

N2 - A novel "on-off-on" super-sensitive conjugated polymer fluorescence sensor (PPE-DPA) was developed and it was applied to realize the continuous recognition of Cu2+ and pyrophosphate (PPi). The fluorescence intensity decreased linearly with the change of Cu2+ from 0.05 to 5.0 μmol L-1 and the limit of detection was 24 nmol L-1. The fluorescence intensity was linearly enhanced with the increase of PPi from 0.5 to 12.0 μmol L-1 and the limit of detection was 230 nmol L-1. In addition, this method was applied to detect PPi in the blood serum and synovial fluid of patients with arthritis and satisfactory results were obtained. Thus, the PPE-DPA is not only an effective tool for detecting Cu2+ and PPi in samples, but also presents a potential way to diagnose arthritis.

AB - A novel "on-off-on" super-sensitive conjugated polymer fluorescence sensor (PPE-DPA) was developed and it was applied to realize the continuous recognition of Cu2+ and pyrophosphate (PPi). The fluorescence intensity decreased linearly with the change of Cu2+ from 0.05 to 5.0 μmol L-1 and the limit of detection was 24 nmol L-1. The fluorescence intensity was linearly enhanced with the increase of PPi from 0.5 to 12.0 μmol L-1 and the limit of detection was 230 nmol L-1. In addition, this method was applied to detect PPi in the blood serum and synovial fluid of patients with arthritis and satisfactory results were obtained. Thus, the PPE-DPA is not only an effective tool for detecting Cu2+ and PPi in samples, but also presents a potential way to diagnose arthritis.

KW - Blood serum

KW - Conjugated polymer

KW - Cu

KW - Fluorescence sensor

KW - Pyrophosphate

KW - Synovial fluid

UR - https://www.scopus.com/pages/publications/85067172125

U2 - 10.2116/analsci.18P576

DO - 10.2116/analsci.18P576

M3 - 文章

C2 - 30713218

AN - SCOPUS:85067172125

SN - 0910-6340

VL - 35

SP - 625

EP - 630

JO - Analytical Sciences

JF - Analytical Sciences

IS - 6

ER -

A conjugated polymer fluorescent sensor for continuous identification of copper(II) and pyrophosphate in blood serum and synovial fluid

Abstract

Keywords

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