Abstract
Objective To investigate the clinical significance of therapeutic drug monitoring of teicoplanin. Methods The clinical data of severe infection patients treated with teicoplanin in the first affiliated hospital of Xi'an Jiaotong University from Apr. 16, 2008 to Sep. 25, 2011, were retrospectively analyzed. A total of 30 patients were divided into 2 groups: MID=533.33mg/d, MID<533.33mg/d. The trough concentration of teicoplanin was measured by HPLC. Results The serum trough concentration of teicoplanin is closely related to initial dose, Pearson correlation is 0.678 and the correlation is significant at the 0.01 level(2-tailed). The C min and the therapeutic effect of patients who were accepted the initial load dose were higher and better than the patients who weren't accepted the initial load dose. There is no statistically difference in two teams with the side-effect of teicoplanin. Conclusion These findings suggest that a regular initial dose of teicoplanin make it possible to rapidly attain an optimal trough concentration and acquire a good therapeutic effect. It is necessary for severe infection patients treated with teicoplanin to monitor drug therapeutic concentration.
| Original language | English |
|---|---|
| Pages (from-to) | 76-80 |
| Number of pages | 5 |
| Journal | Chinese Journal of Antibiotics |
| Volume | 37 |
| Issue number | 1 |
| State | Published - 2012 |
Keywords
- Antibiotic
- Load dose
- Teicoplanin
- Therapeutic drug monitoring