A Case Report of Cutaneous Anthrax Diagnosed by Using a Metagenomic Next-Generation Sequencing (mNGS) Approach

Yushan Liu; Gezhi Zheng; Jing Li; Nan Yang; Juan Li; Zhengwen Liu; Qunying Han; Yingren Zhao; Fenjing Du; Yingli He; Taotao Yan

doi:10.2147/IDR.S411717

A Case Report of Cutaneous Anthrax Diagnosed by Using a Metagenomic Next-Generation Sequencing (mNGS) Approach

Yushan Liu
, Gezhi Zheng
, Jing Li
, Nan Yang
, Juan Li
, Zhengwen Liu
, Qunying Han
, Yingren Zhao
, Fenjing Du
, Yingli He
, Taotao Yan

The First Affiliated Hospital of Xi’an Jiaotong University
Shaanxi Provincial Clinical Medical Research Center of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Anthrax is caused by Bacillus anthracis. Humans are mainly infected through contact with the fur and meat of livestock. The cutaneous form is the most common form. The skin lesions of typical cutaneous anthrax are characterized by shallow ulcers with black crusts, surrounded by small blisters and nonpitting edema of nearby tissues. Metagenomic next-generation sequencing (mNGS) is a new pathogenic detection method which is rapid and unbiased. We reported the first case of cutaneous anthrax diagnosed by mNGS. Ultimately, the man received prompt antibiotic therapy and had a good prognosis. In conclusion, mNGS is proved to be a good method for etiological diagnosis, especially for rare infectious diseases.

Original language	English
Pages (from-to)	3601-3606
Number of pages	6
Journal	Infection and Drug Resistance
Volume	16
DOIs	https://doi.org/10.2147/IDR.S411717
State	Published - 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

case report
cutaneous anthrax
etiology diagnosis
mNGS
metagenomic next-generation sequencing

Access to Document

10.2147/IDR.S411717

Cite this

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title = "A Case Report of Cutaneous Anthrax Diagnosed by Using a Metagenomic Next-Generation Sequencing (mNGS) Approach",

abstract = "Anthrax is caused by Bacillus anthracis. Humans are mainly infected through contact with the fur and meat of livestock. The cutaneous form is the most common form. The skin lesions of typical cutaneous anthrax are characterized by shallow ulcers with black crusts, surrounded by small blisters and nonpitting edema of nearby tissues. Metagenomic next-generation sequencing (mNGS) is a new pathogenic detection method which is rapid and unbiased. We reported the first case of cutaneous anthrax diagnosed by mNGS. Ultimately, the man received prompt antibiotic therapy and had a good prognosis. In conclusion, mNGS is proved to be a good method for etiological diagnosis, especially for rare infectious diseases.",

keywords = "case report, cutaneous anthrax, etiology diagnosis, mNGS, metagenomic next-generation sequencing",

author = "Yushan Liu and Gezhi Zheng and Jing Li and Nan Yang and Juan Li and Zhengwen Liu and Qunying Han and Yingren Zhao and Fenjing Du and Yingli He and Taotao Yan",

note = "Publisher Copyright: {\textcopyright} 2023 Liu et al.",

year = "2023",

doi = "10.2147/IDR.S411717",

language = "英语",

volume = "16",

pages = "3601--3606",

journal = "Infection and Drug Resistance",

issn = "1178-6973",

publisher = "Dove Medical Press Ltd",

}

TY - JOUR

T1 - A Case Report of Cutaneous Anthrax Diagnosed by Using a Metagenomic Next-Generation Sequencing (mNGS) Approach

AU - Liu, Yushan

AU - Zheng, Gezhi

AU - Li, Jing

AU - Yang, Nan

AU - Li, Juan

AU - Liu, Zhengwen

AU - Han, Qunying

AU - Zhao, Yingren

AU - Du, Fenjing

AU - He, Yingli

AU - Yan, Taotao

PY - 2023

Y1 - 2023

N2 - Anthrax is caused by Bacillus anthracis. Humans are mainly infected through contact with the fur and meat of livestock. The cutaneous form is the most common form. The skin lesions of typical cutaneous anthrax are characterized by shallow ulcers with black crusts, surrounded by small blisters and nonpitting edema of nearby tissues. Metagenomic next-generation sequencing (mNGS) is a new pathogenic detection method which is rapid and unbiased. We reported the first case of cutaneous anthrax diagnosed by mNGS. Ultimately, the man received prompt antibiotic therapy and had a good prognosis. In conclusion, mNGS is proved to be a good method for etiological diagnosis, especially for rare infectious diseases.

AB - Anthrax is caused by Bacillus anthracis. Humans are mainly infected through contact with the fur and meat of livestock. The cutaneous form is the most common form. The skin lesions of typical cutaneous anthrax are characterized by shallow ulcers with black crusts, surrounded by small blisters and nonpitting edema of nearby tissues. Metagenomic next-generation sequencing (mNGS) is a new pathogenic detection method which is rapid and unbiased. We reported the first case of cutaneous anthrax diagnosed by mNGS. Ultimately, the man received prompt antibiotic therapy and had a good prognosis. In conclusion, mNGS is proved to be a good method for etiological diagnosis, especially for rare infectious diseases.

KW - case report

KW - cutaneous anthrax

KW - etiology diagnosis

KW - mNGS

KW - metagenomic next-generation sequencing

UR - https://www.scopus.com/pages/publications/85162233384

U2 - 10.2147/IDR.S411717

DO - 10.2147/IDR.S411717

M3 - 文章

AN - SCOPUS:85162233384

SN - 1178-6973

VL - 16

SP - 3601

EP - 3606

JO - Infection and Drug Resistance

JF - Infection and Drug Resistance

ER -

A Case Report of Cutaneous Anthrax Diagnosed by Using a Metagenomic Next-Generation Sequencing (mNGS) Approach

Abstract

UN SDGs

Keywords

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