钠钾干预对成人血浆pentraxin-3的影响

Objective: To explore the responses of plasma pentraxin-3 (PTX-3) to sodium and potassium supplementation so as to investigate the potential role of PTX-3 in salt-induced hypertension. Methods: We enrolled 48 volunteer participants from Liquan County, Shaanxi Province. All the subjects sequentially went through a 3-day normal diet, a 7-day low-sodium diet, a 7-day high-sodium diet, and a 7-day high-sodium plus potassium diet. Plasma concentration of PTX-3 was assessed by ELISA. Results: Subjects with lower PTX-3 tended to have higher body mass index (BMI), diastolic blood pressure (DBP), and mean arterial pressure (MAP). PTX-3 was negatively correlated with BMI, DBP, and MAP. During low-salt period, plasma PTX-3 significantly decreased compared with the baseline [(0.57±0.19)ng/mL vs. (0.72±0.33)ng/mL, P=0.012], but elevated during high-salt period [(0.68±0.26)ng/mL vs. (0.57±0.19)ng/mL, P=0.037]. Potassium supplementation significantly inhibited the salt-induced increase of PTX-3 [(0.56±0.21)ng/mL vs. (0.68±0.26)ng/mL, P=0.015]. PTX-3 was positively correlated with the sodium-to-potassium ratio (r=0.230, P=0.002). The response of PTX-3 was more prominent in salt-sensitive subjects. Conclusion: Dietary sodium and potassium interventions significantly affect circulating PTX-3. Low-salt intake contributes to the decrease of plasma PTX-3 while PTX-3 increases after high-salt intake. Potassium supplementation can inhibit salt-induced increase of PTX-3.