肌萎缩侧索硬化症患者的尿肌酐水平分析

Objective: To analyze the level of urine creatinine of patients with amyotrophic lateral sclerosis (ALS) to explore its clinical value. Methods: We included ALS (ALS group), other neurological diseases(OND) patients and healthy controls (CTRL). We collected all the participants' fresh urine in the morning, measured and analyzed the level of urine creatinine. Results: There were 196 ALS patients, and 108 OND and 90 CTRL subjects in our study. The levels of urine creatinine and serum creatinine were remarkably lower in ALS patients than in OND and CTRL (P<0.01) subjects. The level of urine creatinine was positively associated with the level of serum creatinine (r=0.2786, P=0.0029); the urine creatinine level and BMI on baseline of ALS patients had positive correlation (r=0.1989, P=0.0052). The level of urine creatinine was higher in male ALS patients than in female ALS patients (P=0.0013). The level of urine creatinine in fast-progression ALS group was significantly higher than that in slow-progression (P=0.016). Multivariate linear regression analysis showed that BMI and serum creatinine were factors influencing the level of urine creatinine of ALS patients (P<0.05). Conclusion: The levels of urine and serum creatinine in ALS patients became significantly lower synchronously than those in OND and CTRL subjects. BMI and serum creatinine were the factors influencing the level of urine creatinine of ALS patients. Urine creatinine may be a potential marker for evaluating muscle mass in ALS patients.