肌萎缩侧索硬化症患者延髓区域MRI 皮质厚度特点及对生存的影响

Objective To investigate cortical thickness changes in the face-head region of the primary motor cortex (PMC) and its effect on survival in amyotrophy lateral sclerosis (ALS) patients. Methods A retrospective analysis was performed on 105 ALS patients who underwent head MRI scan at the same time. The A4hf (face-head) region of PMC was used as the region of interest (ROD . According to clinical symptoms, patients were divided into two groups: bulbar involvement and non-bulbar involvement. The differences of clinical features and cortical thickness in ROI were analyzed. According to the symptoms of bulbar palsy, physical examination of nervous system and EMG of tongue muscle, the patients with bulbar palsy were divided into lower motor neuron (LMN) , upper motor neuron (UMN) and LMN + UMN groups. The differences of bulbar subgroup score and ROI of cortical thickness were analyzed. Age at onset, body mass index, delayed time of diagnosis, bulbar subgroup score, and ROI cortical thickness were included in survival analysis. Results CD The ROI cortical thickness was significantly lower in bulbar involvement group than non-bulbar involvement group ( - 0.198 + 0.87 vs. 0.235 + 0.95, P = 0.017). (2) There were no significant differences in the bulbar subgroup scores or cortical thickness of ROI between LMN, UMN and LMN + UMN groups (P>0.05).