经颅交流电刺激对阿尔兹海默病小鼠双侧海马有效连接的干预研究

The effective connectivity in bilateral hippocampus during the Y maze task was analyzed with Granger causality method and the neural mechanism of transcranial alternating current stimulation (tACS) intervention in Alzheimer's disease (AD) was studied from the perspective of connecting brain regions. The mice were divided into four groups: the normal control group, AD group, tACS stimulation group and sham stimulation group. The behavior performance and local field potentials in left and right hippocampus in four groups were recorded during the Y-maze working memory task. Power spectral density in four groups was compared. The Granger causal-ity analysis value (GO between the left and right hippocampus in four groups was analyzed. The correct rate of behavior training in AD group is lower than that of the normal control group, and tACS can increase the correct rate. In both d and 7 bands, power spectral density in AD group is remarkably lower than that in normal control group(P<0. 01), while power spectral density in tACS stimulation group is improved to the level of normal control group. In the d band, tACS stimulation can increase the abnormal GC value of AD mice hippocampus from left hippocampus to right hippocampus and right hippocampus to left hippocampus (from 0. Ill + 0. 002; 0. 109 + 0.003 to 0. 377 + 0.017; 0. 185 + 0. 005), which is close to the normal control group. In the y band, tACS can reduce abnormal GC values between the left and right hippocampus in AD mice (fromO. 145 + 0.002; 0. 127 + 0.003 to 0.074 + 0.001; 0.082 + 0.002) and approach the levels of normal control group. This study illustrates the abnormal effective connectivity between the left and right hippocampus cause the decline in memory of Alzheimer's mice. tACS can improve in the abnormal brain network connectivity between the bilateral hippocampus and in power spectral density in AD mice.