细胞的力学智能

Biological intelligence, which includes features such as perception, memory, learning, prob-lem-solving and decision-making, is widely observed in humans, animals and other higher organisms with nervous Systems. Recent studies have shown that Single cells also exhibit behaviours that re-semble human-like intelligence in their interactions with the microenvironment, such as "multimodal perception", "problem solving", "learning and memory", and "evolutionary adaptation". Cellular intelligence, as a newly proposed and disruptive theoretical concept, raises fundamental questions, including the principles underlying the emergence of cellular intelligence, the mechanisms by which collective cell behaviour emerges as collective intelligence, and the evolutionary drivers for Single cells to evolve into multicellular life forms. As the fields of biomechanics and mechanobiology have advanced, numerous studies have demonstrated the significant influence of the mechanical microenvironment on cellular physiological behaviour. Under mechanical Stimulation, even Single cells exhibit intelligent behaviours similar to those observed in higher organisms. Based on this, the concept of "cellular mechanical intelligence" is proposed in this paper. We summarise the characteristics of intelligent behaviours in terms of mechanical perception, mechanical decision making, mechanical memory and mechanical learning, with the aim of providing new insights and perspectives on the mechanisms underlying cellular mechanical intelligence and its potential applications, such as in cellular intelligent medicine.