纤维介素2在慢性病毒性肝炎患者中的表达水平及临床意义

Objective: To explore the value of soluble fibrinogen-like protein 2 (sFgl2) assay in predicting clinical outcome and prognosis in patients with chronic viral hepatitis. Methods: The level of sFgl2 in serum was tested by ELISA method in 85 patients with chronic hepatitis (42 cases of hepatitis B and 43 ones of hepatitis C), 108 liver cirrhosis patients (35 cases of hepatitis B and 73 ones of hepatitis C), and 72 healthy controls. Spearman correlation was analyzed between sFgl2 level and liver function or Child-Pugh classification. Results: The sFgl2 level was significantly higher in liver cirrhosis group than in chronic hepatitis group and healthy controls. As the Child-Pugh score increased, the sFgl2 level of liver cirrhosis patients increased gradually. Regardless of the etiology, the positive relation between sFgl2 with TBIL and negative relation between sFgl2 with ALB could be detected. However, sFgl2 level did not have correlation with viral load or the level of ALT or AST. Conclusion: The study further confirmed that serum sFgl2 was significantly elevated in patients with liver cirrhosis and that sFgl2 level was positively correlated with Child-Pugh score. It suggests that sFgl2 level is related to the severity of cirrhosis and may become a tool to evaluate the prognosis of cirrhosis.