磁示踪技术用于胃肿瘤标记定位的实验研究

Objective To verify the feasibility and safety of stomach tumor marker localization based on magnetic tracer technique in dogs. Methods Six male Beagle dogs were examined by gastroscopy. Then tracer magnets were sent to the "tumor" locations assumed in advance and fixed near the "tumors" by endoscopic soft tissue clamp. Laparoscopic gastric tumor localization was performed under general anesthesia 24 hours later. The tracer magnet was placed near the tumor on the surface of the stomach through the operating hole after the conventional establishment of laparoscope puncture parallel mirror to explore the tracer magnet. After the two magnets were attracted, the location of the tracer magnet seen under the laparoscope was the location of the gastric tumor, so as to complete the labeling and positioning of the lesion. Results All the 6 Beagle dogs were successfully implanted with tracer magnets under gastroscopy .Twenty-four hours after the gastroscopy, the pursuit magnet was successfully implanted during laparoscopic surgery. The two magnets automatically attracted each other and formed a sandwich structure of "tracer magnet-gastric wall-pursuit magnet" , which completed the location and identification of gastric tumor under the laparoscopy. Conclusion Gastroscopy combined with laparoscopy based on magnetic tracer technique is simple, accurate, safe and feasible.