碳青霉烯类在抗感染治疗中给药方案优化研究进展

The rational use of carbapenem is challenged in critically ill patients by the emergence of drug-resistant pathogens, the alterations of drug pharmacokinetics and the controversy over the pharmacokinetic/pharmacodynamic targets. Therefore, the optimization of carbapenem dosage regimen is imperative. This paper reviewed the research progress on the clinical application and dosage regimen of carbapenem in critically ill patients by reviewing the relevant domestic and international literatures. In order to improve clinical efficacy and reduce adverse reactions, the administration of carbapenem can be optimized by adjusting dosage, changing the administration interval, adjusting infusion time, performing therapeutic drug monitoring, combining with other drugs and using individual administration software, which is based on the physiological and pathological of critically ill patients and the pharmacokinetic/pharmacodynamic of carbapenem.