疾病状态下的药物代谢处置变化及其机制研究

Xiaofang Zhang; Fang Zhou; Guangji Wang; Jingwei Zhang

doi:10.7501/j.issn.1674-6376.2019.03.001

疾病状态下的药物代谢处置变化及其机制研究

Translated title of the contribution: Changes and related mechanisms of drug metabolism and disposition under diseases status

Xiaofang Zhang
, Fang Zhou
, Guangji Wang
, Jingwei Zhang

China Pharmaceutical University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Dysregulation of drug metabolizing enzymes and transporters(DMET) during diseases leads to altered pharmacokinetics. It has profound impact on drug safety and efficacy. The mechanisms of this dysregulation include inflammation associated signal pathway/nuclear receptor, epigenetic regulation and post-translational modification. This article reviews the regulation of DMET under disease status and its related mechanisms. The application of physiologically-based pharmacokinetic model in rational drug usage in patients is also summarized. Our work will benefit personalized medicine according to DMET phenotype.

Translated title of the contribution	Changes and related mechanisms of drug metabolism and disposition under diseases status
Original language	Chinese (Traditional)
Pages (from-to)	369-377
Number of pages	9
Journal	Drug Evaluation Research
Volume	42
Issue number	3
DOIs	https://doi.org/10.7501/j.issn.1674-6376.2019.03.001
State	Published - Mar 2019
Externally published	Yes

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title = "疾病状态下的药物代谢处置变化及其机制研究",

abstract = "Dysregulation of drug metabolizing enzymes and transporters(DMET) during diseases leads to altered pharmacokinetics. It has profound impact on drug safety and efficacy. The mechanisms of this dysregulation include inflammation associated signal pathway/nuclear receptor, epigenetic regulation and post-translational modification. This article reviews the regulation of DMET under disease status and its related mechanisms. The application of physiologically-based pharmacokinetic model in rational drug usage in patients is also summarized. Our work will benefit personalized medicine according to DMET phenotype.",

keywords = "disease, drug metabolizing enzyme and transporter, physiologically-based pharmacokinetic model, rational usage of medicines, regulating mechanism",

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AU - Zhang, Xiaofang

AU - Zhou, Fang

AU - Wang, Guangji

AU - Zhang, Jingwei

PY - 2019/3

Y1 - 2019/3

N2 - Dysregulation of drug metabolizing enzymes and transporters(DMET) during diseases leads to altered pharmacokinetics. It has profound impact on drug safety and efficacy. The mechanisms of this dysregulation include inflammation associated signal pathway/nuclear receptor, epigenetic regulation and post-translational modification. This article reviews the regulation of DMET under disease status and its related mechanisms. The application of physiologically-based pharmacokinetic model in rational drug usage in patients is also summarized. Our work will benefit personalized medicine according to DMET phenotype.

AB - Dysregulation of drug metabolizing enzymes and transporters(DMET) during diseases leads to altered pharmacokinetics. It has profound impact on drug safety and efficacy. The mechanisms of this dysregulation include inflammation associated signal pathway/nuclear receptor, epigenetic regulation and post-translational modification. This article reviews the regulation of DMET under disease status and its related mechanisms. The application of physiologically-based pharmacokinetic model in rational drug usage in patients is also summarized. Our work will benefit personalized medicine according to DMET phenotype.

KW - disease

KW - drug metabolizing enzyme and transporter

KW - physiologically-based pharmacokinetic model

KW - rational usage of medicines

KW - regulating mechanism

UR - https://www.scopus.com/pages/publications/85135778773

U2 - 10.7501/j.issn.1674-6376.2019.03.001

DO - 10.7501/j.issn.1674-6376.2019.03.001

M3 - 文章

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SN - 1674-6376

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SP - 369

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JO - Drug Evaluation Research

JF - Drug Evaluation Research

IS - 3

ER -

疾病状态下的药物代谢处置变化及其机制研究

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