感 染 对 慢 性 阻 塞 性 肺 疾 病 系 统 性 炎 症 反 应 的 影 响

Objective: To explore the influence of infection on clinical inflammatory indicators in acute exac‑ erbation and remission stage of chronic obstructive pulmonary disease (COPD). Methods: We en‑ rolled 30 cases of acute exacerbation COPD and 15 patients in remission stage, and 15 cases in the control group. The routine blood, C‑reactive protein (CRP), procalcitonin levels, and lung function were recorded. The enzyme‑linked immunosorbent assay (ELISA) was used to detect the concentra‑ tion of interferon (IFN)‑γ, interleukin (IL)‑2, IL‑4, and IL‑13 in plasma. Results: The concentration of IFN‑γ in COPD patients (involved the acute and remission period) was significantly higher than that in control group (P<0. 05). The concentration of IL‑2 in COPD patients was significantly lower than that in control group (P<0. 01). The concentration of IL‑4 and IL‑13 in acute COPD group were higher than those in control group (P<0. 05). When the serum procalcitonin was less than 0. 1 ng/mL, the number of neutrophils, percentage of neutrophils, and CRP levels were significantly higher in COPD patients as compared with those in control group, the concentration of IFN‑γ in the COPD group was higher than that in control group (P<0. 05), while the concentration of IL‑2 was lower than that in control group (P<0. 01). Conclusion: Regardless of the infection factors, systemic inflammatory response to the activation and conversion of T cells in COPD is consistent. The inflam‑ matory state is still the stage of activation of Th1. IFN‑γ is stimulated and IL‑2 is inhibited. Inflam‑ mation exists in the whole process of COPD, which is the core of systemic inflammation of COPD.