快速眼球运动睡眠时间与心绞痛在不同性别中的相关性分析

Objective: To investigate the relationship between rapid eye movement sleep (REM) and the incidence of angina pectoris (AP) in different genders. Methods: We recruited 2710 participants from the Sleep Heart Health Study with an average age of (61.7±10.9)y, of whom 1 103 (40.7%) were male and 1 607(59.3%) were female. The participants were divided into grade 1 (<20%), grade 2 (20%-25%), and grade 3 (>25%) according to the percentage of REM sleep time (REM%). Complete polysomnography data and medical records were collected for all the participants. Multivariate logistic regression analysis was used to characterize the independent association between REM% and the occurrence of AP. Results: REM% in the three groups varied significantly in age, body mass index (BMI), smoking, AHI, diabetes, and hypertension (P<0.05). In addition, the incidence of AP in patients with grade 3 of REM% was significantly higher than those with grade 1 and 2 in both men and women. After adjusting for covariates such as age, ethnicity, AHI, marital status, education level, BMI, diabetes, hypertension, and smoking status, multiple logistic regression analysis showed that REM% >25% in women was closely related to AP (OR=1.523; 95% CI:1.132-2.051, P=0.006). Conclusion: Participants with REM sleep time >25% have a significantly increased prevalence of AP in women, but not in men.