微纳材料在氢分子医疗中的应用

Since the selective antioxidant propcrtics of hydrogen molecules were first discovered in 2007, hydrogen molecules has rapidly become a research focus in modern medicine. In numerous studies, its positive effects in various animal modcls and human diseases have been demonstrated.In response to thc issucs of low utilization, difficulty in Controlling release, and insufficicnt targeting associated with traditional hydrogcn molcculc dclivcry methods (such as inhaling hydrogcn gas, drinking hydrogcn-rich water, and injecting hydrogcn saline), micro-nano materials offer ncw Solutions. Starting from thc hydrogen release mechanism of micro-nano materials, two main strategies are discussed in this rcvicw: hydrogcn adsorption and in situ hydrogcn release, as well as their cutting-edge applications in synergistic therapies. Hydrogcn adsorption relies on physical or chcmical adsorption for hydrogen storage, with release controlled by cxtcrnal Stimuli such as temperature and pressure. In contrast, in situ hydrogcn release utilizes chcmical reactions, photothermal catalysis, or biological mechanisms to generate hydrogcn in specific pathological environments, achieving higher targeting and controllability through endogenous responses or exogenous regulation. Utilizing micro-nano materials as a medium, and combining thc anti-inflammatory and anti-tumor funetions of hydrogen molecules, hydrogcn molecules can significantly enhance the therapeutic effect on tumor diseases through synergistic interactions with chemotherapy drugs, photothermal therapy, and photodynamic therapy. In this rcvicw, current challenges, including issues of biosafety, targeting, and scalablc produetion arc also summarized, and futurc directions such as the design of smart responsive materials combined with multimodal synergistic therapy using hydrogen molecules arc proposed, to further improve therapeutic precision and efficaey. This provides guidance for subsequent advancements in hydrogen molecular medicinc based on micro-nano materials.