双相障碍患者肠道菌群相对丰度与临床症状及认知功能的相关性

Objective: To study the correlation of the relative abundance of gut microbiome with cognitive function and clinical symptoms in bipolar disorder (BD). Methods: We recruited 23 healthy controls (control group) and 27 BD patients (BD group), the latter of which consisted of 17 patients with manic episode (BDM group) and 10 patients with depressive episode (BDD group). We used MCCB to compare the cognitive function and used 16S rRNA sequencing technology to obtain gut microbiome diversity among the groups. We analyzed the correlation of the relative abundance of gut microbiome with cognitive function and clinical symptoms in BD. Results: ① Cognitive function: The scores of symbol encoding and maze of BD group and BDM group were significantly lower than that of HC group (P<0.05). The score of Hopkins Verbal Learning Test of BD group was significantly lower than that of HC group (P<0.05). The score of Hopkins Verbal Learning Test of BDD group was significantly lower than that of HC group (P<0.01) and BDM group (P<0.05). ② Correlation of the relative abundance of gut microbiome with cognitive function and clinical symptoms: The relative abundance of Bacteroides_plebeius was significantly positively related to age (r=0.40, P<0.01), and that of Bifidobacterium_adolescentis was significantly negatively related to the total score of YMRS (r=-0.53,P<0.05). The relative abundance of Bifidobacterium was significantly negatively related to the total score of MADRS (r=-0.70,P<0.05) and the score of dysphoria factor (r=-0.64,P<0.05). The relative abundance of Escherichia-Shigella was significantly negatively related to the score of retardation factor (r=-0.66, P<0.05). That of Eschericha_coli was significantly negatively related to the score of retardation factor (r=-0.66, P<0.05). The relative abundance of adolescentis in BDM group was significantly negatively related to cognitive function (P<0.05). The relative abundance of adolescentis, Eschericha_coli and Escherichia-Shigella in BDD group was significantly associated with cognitive function (P<0.05). Conclusion: BD patients have cognitive impairment and changes in the relative abundance of gut microbiome during acute episode, and these changes are correlated with the severity of symptoms and cognitive function.