单相抑郁症患者抗抑郁治疗对血糖血脂的影响

Objective: This study investigated the occurrence and possible causes of metabolic abnormalities in patients with unipolar depression. Methods: We recruited 103 hospitalized patients with unipolar depression and 100 healthy controls. The patient group was treated with antidepressants for 3 weeks. Metabolic indicators (fasting blood glucose, total cholesterol, triglycerides, high-density lipoprotein) were measured before and after treatment. Results: Fasting blood glucose, total cholesterol and high-density lipoprotein were significantly higher in patients with unipolar depression than in healthy controls (P<0.05). The metabolic index did not significantly differ between the two groups after treatment (P>0.05). After treatment with antidepressants, serum fasting blood glucose level was significantly lower than the baseline value (P<0.05). Fasting blood glucose and total cholesterol were significantly higher in patients with recurrent unipolar depression than in the healthy controls (P=0.049, P=0.031). The patients aged above 30 years had significantly higher fasting blood glucose and total cholesterol levels than those aged 30 or younger (P=0.001, P=0.016). Fasting blood glucose level was positively correlated with the number of episodes, and a regression equation could be established as Y_{fasting blood glucose}=0.26x_{incidence times} +4.01. Conclusion: Repeated episodes of depression increase the risk of metabolic problems. Antidepressant treatment helps improve fasting blood glucose. The risk of unilateral depression metabolism may be related to the recurrent disease and has little to do with drug treatment.