儿茶酚-O-甲基转移酶基因多态性rs4680对抗精神病药物疗效的影响

Objective: To investigate the effect of the main single nucleotide polymorphisms (SNP) rs4680of catechol-O-methyltransferase (COMT) gene on the efficacy of antipsychotic drugs by meta-analysis. Methods: PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and the Wanfang Database were searched to identify studies which researched the association of rs4680 with the efficacy of antipsychotic drugs. The data were extracted and analyzed by Stata14.0 software under the dominant model. The correlation was determined by the odds ratio (ORs) and the 95% confidence interval (95% CI); the stability of the results was analyzed by the sensitivity analysis; the publication bias was investigated by funnel plot. Results: A total of 13 studies were included, involving 1,439 schizophrenic patients. The pooled results showed that rs4680 significantly affected the efficacy of antipsychotic drugs in the dominant model. Compared with that of GG genotype carriers, the response rate of AA or AG genotype carriers treated with antipsychotic drugs was higher (OR=1.31, 95% CI: 1.04-1.66). The sensitivity analysis showed that after removing two small sample studies, the outliers of the funnel plot, the pooled results were not significantly different (OR=1.25, 95% CI: 0.98-1.58), indicating that there was a certain degree of instability in the meta-analysis results. Conclusion: rs4680 may affect the efficacy of antipsychotic drugs. This result needs to be further validated due to the limitations of the number of studies and the presence of unstable factors.