低剂量螺旋 CT 肺癌筛查的卫生经济效益及其结合戒烟干预的研究进展

Objective To summarize the research progress on health economic evaluation of low-dose computed tomography (LDCT) screening for lung cancer and the effects of screening combined with smoking cessation intervention, so as to provide reference for developing appropriate lung cancer screening strategy in China. Methods With "lung neoplasms, early detection, cost-benefit analysis, smoking cessation intervention" as the keywords, the relevant literatures of PubMed, CNKI and Wanfang database were retrieved from August 2011 to September 2023. Inclusion criteria: (1) Health economics evaluation of lung cancer screening; (2) Assessing the effect of lung cancer screening combined with smoking cessation intervention; (3)Exploring the methods of smoking cessation intervention. Exclusion criteria: (1) Articles with the above keywords but unrelated content; (2)Conference and commentary articles; (3)Studies which were controversial. Finally, 37 literatures were included. Results Conducting LDCT screening in high-risk populations is economically feasible, and screening programs may vary slightly in different countries and regions; The research results in China are relatively similar, with most believing that conducting annual screening from the age of 50 or 55 is economically viable. The screening admission criteria in research are often set based on parameters such as starting and ending screening age, smoking history, etc, Lung cancer screening combined with smoking cessation interventions offers more health benefits and is more cost-effective than screening alone. Conclusion It is necessary to develop appropriate screening inclusion criteria tailored to national circumstances, and explore effective ways to combine screening with smoking cessation intervention, so as to improve the screening effect and maximize the social and economic benefits.