丝素蛋白/聚乳酸定向孔支架的制备及表征

To study the preparation of silk fibroin/polylactic acid orientation-structured scaffold and its material properties, and to explore its possibility as scaffold material in tissue engineering. After mixing silk fibroin solution with polylactic acid solution, the scaffold was prepared by directional freeze-drying technology. The micropore structure was observed by scanning electron microscopy, and porosity, mechanical strength and in vitro degradation were tested. Scanning electron microscope analysis showed that the scaffold was anisotropic and had directional pore structure. The test results showed that the porosity was higher than 80%, and the scaffold had a certain mechanical strength and can be degraded gradually in buffer solution. Silk fibroin protein/polylactic acid orientation-structured scaffold has high porosity, which is good for cell adhesion and material exchange. The scaffold can provide mechanical support for cell growth and can be degraded. Accordingly, it can be used as scaffold material in tissue engineering.